October 5-6, 2020
Webinar
2nd RESOLUTION DAYS
The resolution of inflammation,
opportunities for
innovative
therapeutics?
Organizers:
Aline Bozec / Markus Hoffmann / Sylvain Perruche
Programme of the Webinar
The resolution of inflammation:
opportunities for innovative therapeutics ?
MONDAY, OCTOBER 5
14:45 Welcome address (Aline Bozec & Markus Hoffmann)
15:00-16:40 Mediators of resolution
(Discussion leaders: Amiram Ariel & Aline Bozec)
Jesmond Dalli, Lipid Mediator Unit, Queen Mary University of London, UK
"Immunoresolvents in the maintenance of homeostasis and the resolution of inflammation"
Gerhard Krönke, Department of Medicine 3, Friedrich Alexander Universität Erlangen-Nürnberg, DE
"Macrophages as gatekeepers of inflammation"
Belen Garcia-Fojeda, University Complutense of Madrid, ESP
"Pulmonary surfactant lipids act as a brake on the IL-4Rα-mediated alveolar macrophage
shift to repair mode"
Vugar Azizov, Department of Medicine 3, Friedrich Alexander Universität Erlangen-Nürnberg, DE
"Acetate accumulation in secondary lymphoid organs upon alcohol consumption modulates
TFH cell dynamics"
Margot Lavy, OSE Immunotherapeutics, Nantes, FRA
"Characterisation of the Resolvin E1 Receptor ChemR23 in macrophages in a context of
mesothelioma and breast cancer"
17:00–18:15 Tissue Imaging in Inflammation
(Discussion Leaders: Tobias Bäuerle & Anika Grüneboom)
Matthias Gunzer, Institute of Experimental Immunology and Imaging, University of Duisburg-Essen, DE
"Whole organ quantitative biology under to study physiological and pathological neutrophil
migration"
Stefan Uderhardt, Department of Medicine 3, Friedrich Alexander Universität Erlangen-Nürnberg, DE
"Visualizing Tissue Biology at Sites of Damage: Of Protectors and Effectors in Inflammation"
Zoltan Winter, Optical Imaging Centre Erlangen, DE
"Investigation of eosinophil-extravasation in mouse ear using Deep 3D penetration imaging"
18:15-19h15 Short abstract session 1: Cytokines and beyond
(Discussion leader: Darja Andreev)
Susanne Adam, Department of Medicine 3, Friedrich Alexander Universität Erlangen-Nürnberg, DE
"Treatment with JAK-inhibitors baricitinib and tofacitinib increases bone mass in steady-state
and pathological conditions in vivo"
Andreas Wild, Department of Immune Modulation, Friedrich Alexander Universität Erlangen-Nürnberg, DE
"CD83 Expressed on Dendritic Cells and Microglia Controls Inflammatory Autoimmune Responses
and Resolution of Inflammation within the CNS"
Heike Schmitt, Department of Medicine 1, Friedrich Alexander Universität Erlangen-Nürnberg, DE
"IL-23R dependent mechanisms determining the function of humanmucosal macrophages in
chronic intestinal inflammation"
Mircea Chiriac, Department of Medicine 1, Friedrich Alexander Universität Erlangen-Nürnberg, DE
"IL-20 controls the resolution of intestinal inflammation"
TUESDAY, OCTOBER 6
09:30-10:30 Clearance of dead cells and resolution of Inflammation
(Discussion leaders: Jonathan Jantsch & Sylvain Perruche)
Laurent Yvan-Charvet, Mediterranean Molecular Medicine Center, University of Nice, FR
"Macrophage glutaminolysis, the good, the bad and the umami"
Amiram Ariel, University of Haifa, ISR
"IFNβ is a Novel Effector Cytokine in Resolving Inflammation and Skin Fibrosis"
10:30-11:15 Keynote lecture (Lars Klareskog)
"Pathways to rheumatoid arthritis; how can we prevent autoimmunity from resulting in
inflammation?"
11:15–12:00 Short abstract session II: Cellular aspects of resolution
(Discussion leader: Maximilien Euler)
Darja Andreev, Department of Medicine 3, Friedrich Alexander Universität Erlangen-Nürnberg, DE
"Asthma-triggered accumulation of resident eosinophils in the synovium primes the resolution of
inflammatory arthritis"
Maarten van der Linden, Citryll BV, Oss, NL
"Therapeutic ACPA inhibits NET formation: a promising therapeutic for inflammatory
and autoimmune diseases"
Stefanie Westermann, Mikrobiologisches Institut, Friedrich Alexander Universität Erlangen-Nürnberg, DE
"RELMα-expressing macrophages are critical in the resolution of helminth-induced lung
inflammation"
13:00-15:15 Metabolic changes pertaining to inflammation and resolution
(Discussion leaders: Martin Böttcher & Gerhard Krönke)
Jonathan Jantsch, Institute of Medical Microbiology and Hygiene, University of Regensburg, DE
"How macrophages detect sodium"
Mario Lauterbach, Institute of Innate Immunity, University of Bonn, DE
"Temporal adaptations in macrophage metabolism modulate the inflammatory response
to LPS"
Triantafyllos Chavakis, University Carl Gustav Carus, Dresden, DE
"Del-1 in resolution of Inflammation"
Baplu Rai, Mikrobiologisches Institut, Friedrich Alexander Universität Erlangen-Nürnberg, DE
"Mechanisms underlying the resolution of chronic cutaneous leishmaniasis in absence of myeloid a
arginase 1"
Sabine Vettorazzi, Department of Biology, Institute for Comparative Molecular Endocrinology, Ulm, DE
"Guardians of the inflammatory processes – Glucocorticoids in synergy with inflammation and
under mouse intensive care management resolve inflammation"
Kerstin Dürholz, Department of Medicine 3, Friedrich Alexander Universität Erlangen-Nürnberg, DE
"Microbiota-derived metabolite induced mechanisms during resolution of inflammation"
Kodi Ravichandran, Center for Inflammation Research, VIB-University of Gent, BE
(rescheduled from clearance session)
15:45–18:15 Tissue specific aspects of resolution
(Discussion leaders: Markus Hoffmann & Hans Kiener)
Caroline Ospelt, Center of Experimental Rheumatology, University of Zurich, CH
"Site-specific effects of synovial fibroblasts on joint inflammation"
Adam Croft, Institute of Inflammation and Ageing, University of Birmingham, UK
"Restoring order to the joint: targeting pathogenic fibroblasts in inflammatory Arthritis"
Francesco Dazzi, Division of Cancer Studies, King's College London, UK
"In vivo stromal cell apoptosis controls inflammation"
Leo Joosten, Radboud University, NL
"Urate Induced Epigenetic Reprogramming of Myeloid cells"
Hans Kiener, Department of Medicine 3, Medical University of Vienna, Austria
"The synovial fibroblast network cell-to-cell organelle transfer responds to mitochondrial damage"
Jasna Friscic, Department of Medicine 3, Friedrich Alexander Universität Erlangen-Nürnberg, DE
"The complement system drives inflammatory memory via metabolic reprogramming of
synovial fibroblasts"
18:15-19:00 Closing lecture
Ira Tabas, Department of Medicine, Columbia University, USA
"Macrophage Metabolism During Efferocytosis"
19:00-19:10 Closing comments