tentative program
 

The resolution of inflammation,

new avenues and opportunities for innovative therapeutics?

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MONDAY, APRIL 7th

Lobby

 

18:00–19:00, Arrival and Registration

 

 

TUESDAY, APRIL 8th

Room Frankfurt 2

08:30, Welcome Address

 

08:45–14:45

New mediators and mechanisms

Room Frankfurt 2

Chairs: Stephanie Dakin and Andreas Weigert

 

Dipak Panigrahy Beth Israel Deaconess Medical Center, US

“SPMs & the Resolution of Inflammation in Cancer”

 

Stefan Offermanns Max Planck Institute for Heart and Lung Research Bad Nauheim, DE

"How are cellular SPM effects mediated?"

 

Selected talk from abstracts:

A. Weigert Goethe-University Frankfurt, DE

Abstract #26 “Interleukin-38 at the crossroads of auto-inflammation and anti-tumor immunity”

 

10:45, Coffee break

Gallery and Lobby

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Kiavash Movahedi University of Brussels, BE

"The fate of brain macrophages following disease resolution"

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Selected short talk from abstracts:

T. Montero-Melendez Queen Mary University of London, UK

Abstract #36 “Therapeutic senescence using melanocortins to induce inflammation resolution”

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12:30, Lunch

hotel restaurant

 

14:00

Jesmond Dalli Queen Mary University of London, UK

"Unlocking SPM Pathways: Bridging Inflammation Resolution and Tissue Repair to Human Health"

 

14:45–18:45

Resolution and ageing

Room Frankfurt 2

Chairs: Susanne Behlke and Jesmond Dalli

 

Kodi Ravichandran Washington University School of Medicines, USA

"Efferocytosis by phagocytes – challenges to having a good meal"

 

Oliver Werz Friedrich Schiller University Jena, DE

“Regulation of lipoxygenases in innate immune cells to promote inflammation resolution”

 

Angela Goncalves DKFZ German Cancer Research Center, DE

 

17:00, Coffee break

Gallery and Lobby

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2 Selected talks from abstracts:

T. Burstyn-Cohen The Hebrew University, IS

Abstract #46 “Microglia Development, Phagocytosis and Inflammation are Regulated by PROS1”

 

C. Gerner University of Vienna, AT

Abstract #53 “Investigating molecular mechanisms of the pro-resolving effects of antioxidant supplementation and extracorporeal photopheresis”

 

2 Selected short talks from abstracts:

L. Soong University Of Texas Medical Branch, USA

Abstract #16 “Unique Cellular and Humoral Immunity Profiles in Preclinical Models of Self-limiting versus Severe Scrub Typhus”

 

G. Merheb Université Paris Cité FR

Abstract #75 “Effects of Omega-3 and SPM on Human Coronary Vascular Tone Induced by Neurotransmitters”

 

19:00, Dinner

hotel restaurant

19:00-22:00, Poster Session I

Room Frankfurt 1

​

 

WEDNESDAY, APRIL 9th

08:30–14:55

Resolution and metabolism

Room Frankfurt 2

Chairs: Tal Burstyn-Cohen and Kodi Ravichandran

 

Ingrid Fleming Goethe-Universität Frankfurt, DE

"Targeting TGF-b signaling by deleting SMOC1 prevents the resolution of inflammation"

 

Ulrich Matt Universitätsklinikum Gießen und Marburg, DE

"Cell type specific efferocytosis instructs macrophage function during resolution of inflammation"

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10:30, Coffee break

Gallery and Lobby

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2 Selected talks from abstracts:

D. Steinhilber Goethe University Frankfurt, DE

Abstract #10 “Canonical and noncanonical functions of 5-lipoxygenase in the onset and resolution of inflammation”

 

M. Subramanian Queen Mary University of London, UK

Abstract #12 “Macrophages are critical for clearance of neutrophil extracellular traps in tissues”

 

3 Selected short talks from abstracts:

P. M. Jordan Friedrich Schiller University Jena, DE

Abstract #7 “Screening of anti-inflammatory natural products uncovers bioactive candidates for promoting endogenous inflammation resolution signals”

 

A. S. Kahnt Goethe University, DE

Abstract #50 “Cleaning-up the Mess - Lipoxygenase-dependent Oxylipin Formation During the Time Course of Inflammation in Human Monocyte-derived Macrophages”

 

H. Badji Université Paris Cité, FR

Abstract #85 “Unlocking the Potential of Specialized Pro-Resolving Mediators in Pulmonary Hypertension: A New Approach to Vascular Tone Regulation”

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12:40, Lunch

hotel restaurant

 

13:55

Sponsored talk: Bruno Fink Noxygen Science Transfer & Diagnostics GmbH
“A plant-based dietary supplement exhibits significant effects on markers of oxidative stress, inflammation and immune response in subjects recovering from respiratory viral infection. A randomized, double-blind clinical study using Vitamin C as 5 a positive control”

 

14:10

Johan Garaude Université de Bordeaux, FR

"Microbial viability drives immunometabolic responses of macrophages"

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14:55-19:05

Resolution and regeneration

Room Frankfurt 2

Chairs: Astrid Stephanie Kahnt and Sylvain Perruche

 

Mikael Simons Technical University Munich, DE

“Role of the Innate Immune System in Myelin Repair within the Central Nervous System”

 

Pedro Melgar-Lesmes University of Barcelona, ES

"The paradigm of macrophages on liver fibrosis resolution and regeneration"

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16:25, Coffee break

Gallery and Lobby

​

Sven Reischauer Justus Liebig University Gießen, DE

 

2 Selected talks from abstracts:

S. A. Rizo University of Montreal, QC

Abstract #68 “Interferon-beta drives the resolution of neutrophil-mediated pulmonary inflammation by switching between LTB4 and specialized pro-resolving lipid mediator biosynthesis”

 

N. Prevete University of Naples Federico II, IT

Abstract #70 “Formyl peptide receptor 1 signalling strength orchestrates the switch from inflammation to resolution in colon cancer cells”

 

2 Selected short talks from abstracts:

J. Chen Queen Mary University of London, UK

Abstract #47 “Targeting Fpr1/Fpr2 Signaling to Mitigate Secondary Organ Damage in Inflammatory Arthritis”

 

M. Cattaneo Goethe University Hospital, DE

Abstract #67 “Combination therapy of autoimmune liver diseases by administration of an anti-CD3 antibody and a CXCR3 antagonist”

 

19:15, Dinner

hotel restaurant

19:15-22:00, Poster Session II

Room Frankfurt 1

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THURSDAY, APRIL 10th

08:30-11:55

Translational resolution

Room Frankfurt 2

Chairs: Susanne Behlke and Johan Garaude

 

Andreas Ramming University Clinic Erlangen, DE

“Active Role of Fibroblasts during Onset and Resolution of Arthritis”

 

Stephanie G Dakin University of Oxford, GB

"Primed to resolve: The shoulder capsule reveals a cellular basis for resolving inflammatory fibrosis"

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10:00, Coffee break

Gallery and Lobby

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2 Selected talks from abstracts:

S. Gupta University of Rostock, DE

Abstract #80 “Comparative Analysis of Multicomponent Tr14 and Single-Component Diclofenac in Modulating the Neutrophil-Macrophage Axis for Inflammation Resolution”

 

N. Ben Jashar University of Haifa, IS

Abstract #17 “The BiST of Burden: Harnessing biased STING agonists to enhance the resolution of inflammation and limit tissue fibrosis”

 

2 Selected short talks from abstracts:

M. Denkewitz University Hospital, DE

Abstract #40 “Coronaviruses impair resolution phase in monocytes via aberrant interferon signalling”

 

A. Chakravarty University of Zurich, DE

Abstract #84 “Minor Association of Oxylipins with Adolescent Depression: A Case-Control Study”

 

12:00, Lunch

hotel restaurant

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13:30-17:00

iiSIAR Study Group Session

Innate immunity in sterile inflammation, autoimmunity, and their resolution

Room Frankfurt 2

 

13:30, KEYNOTE

Chairs: Zsuzsa Szondy and Amiram Ariel

Nicolas Manel Institut Curie, FR

"Activation of nuclear cGAS by self DNA"

 

14:15-16:10, SESSION 1

3 selected talks from Forum:

R. Bernhard CNRS, FR

Abstract #22 “Chronic ozone induced Th2 response mimicking COPD”

 

A. F. Valledor University of Barcelona, SP

Abstract #78 “Selective cooperation of Liver X Receptors and Inflammation-Induced C/EBPβ impacts CD38 expression”

 

A. Lučiūnaitė Vilnius University, LTU

Abstract #34 “Investigation of inflammasome activation by phagocytosed particles”

 

15:15, Break

Gallery and Lobby

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15:25, KEYNOTE

Chairs: Annabel Valledor and Maciej Kurpisz

Anne Dejean Institut Toulousain des Maladies Infectieuses et Inflammatoires, FR

"Eomes, a new actor in shaping Tregs identity and plasticity"

 

16:10-17:10 SESSION 2

3 selected talks from Forum:

Z. Szondy University of Debrecen, HU

Abstract #61 “INVOLVEMENT OF ADENOSINE RECEPTORS IN THE REGULATION OF SKELETAL MUSCLE REGENERATION IN MICE”

 

T. Bruurmijn Citryll B.V., NL

Abstract #44 “Anti-citrullinated histone antibody CIT-013 reduces inflammation by targeting NETs, highlighting its therapeutic potential in Rheumatoid Arthritis.”

 

C. Testini Uppsala University, SE

Abstract #91 “Lyve1+ macrophages contribute to vascular density and perfusion important for tissue normalization during healing of ischemic injuries”

 

17:15, closing remarks

17:30, end

 

 

FRIDAY, APRIL 11th

Departure